The development on North Wales Business Park includes a 79-bed dementia care centre, private surgical unit, brain injury unit and children's nursery.
Some local groups are concerned about the proximity of the site next to the gothic Gwrych Castle.
The firm behind the ?16m plans will not comment until after Wednesday's planning meeting.
A report to Conwy council's planning committee recommends conditional permission, subject to "satisfactory information on the proposal's impact on the setting of Gwrych Castle and its grounds".
The document gives further details of the proposals, shown on the website of the agents, Liverpool-based Gill Dodd Architects.
'Gigantic folly'Proposals include a 26-bed surgical unit with two operating theatres.
It also features an acquired brain injury (ABI) unit with 30 en suite bedrooms, consulting rooms and a hydrotherapy pool as well as a 79-bed dementia unit with communal lounges and dining areas.
Gwyrch Castle was was bought by a developer in 2007 amid plans to develop it into a hotelThe agents predict the development will create 173 full-time and 112 part-time jobs, according to the application.
A separate children's nursery would employ 20 full-time workers, while the remainder employed in the medical facilities.
Welsh historical monument society Cadw says the proposal would have a detrimental impact on the setting of Gwrych Castle's gardens and parkland, but could be mitigated through appropriate landscaping.
The Welsh Historic Gardens Trust "strongly opposes" the development, due to the impact on the setting of the grounds of Gwrych Castle.
The Grade I listed "gigantic folly" was described as a "magnificent example of a Romantic castellated mansion," dating from the 1820s.
It was bought by a developer in 2007 amid plans to develop it into a hotel.
Meanwhile, GPs at nearby Gwrych Medical Centre have also submitted objections, saying there is no local need for such a large development, adding that it would attract clients from outside the area.
They go on to say the addition of highly dependent patients would put a considerable strain on their resources, along with local mental health services.
They say it is their understanding that no such additional resources will be provided, adding the company behind the plans, Marantomark, has not consulted with them.
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